The box H/ACA pseudouridine synthase complex guides modification of small nucleolar and Cajal body ribonucleoproteins (sno/scaRNAs), which are essential for maturation of the ribosome and ...

This further allowed the group to identify five conserved pseudouridine sites on the 3’ end of SARS-CoV-2 sub-genomic RNAs, which could potentially be beneficial to the virus in immune evasion.

Pseudouridine (Ψ) is widely distributed in mRNA and various non-coding RNAs in yeast and mammals, and the specificity of its distribution has been determined. However, knowledge about Ψs in the RNAs ...

Pseudouridine is a modification of cellular RNAs that is widespread in nature, particularly in vertebrate RNA. Back in 2005, a groundbreaking study showed that pseudouridine in synthetic mRNA ...

Colorectal cancer (CRC) is a globally prevalent malignancy with high morbidity and mortality rates, closely linked to aberrant epigenetic modifications. Among these, pseudouridine (Ψ), one of ...

PseudoUridine (Ψ) is a post-transcriptional RNA modification that alters RNA-RNA and RNA-protein interactions and affects gene expression. PseudoUridine modification is also named "fifth base" since ...

The global Pseudouridine market size was significantly robust in 2021 and is expected to register a steady revenue CAGR over the forecast period (2023-2033). Revenue growth of the global Pseudouridine ...

“At a biochemical level, pseudouridine affects some of the fundamental properties of RNA,” Gilbert said. “In particular, changing a uridine to a pseudouridine stabilizes RNA duplexes — base pairing ...

EnginZyme reports that it has patented a process to synthesize pseudouridine, a key ingredient in mRNA COVID-19 vaccines. The company and its CDMO partner, Ajinomoto Bio-Pharma Services, say they ...