Results: PU-H71 has potent anti-myeloma activity with IC50 achieved in HMCLs with concentrations ≤ 100 nM at 24 hours. PU-H71 activates the unfolded protein response and increases apoptosis of HMCLs.

Further, PU-H71 induced apoptosis in the presence of stromal co-culture or cytoprotective survival signals. Finally, genetic knockdown of HSP90 and its client AKT, but not BTK, reduced CLL viability.

Using PU-H71 beads we showed that some of the critical proteins, including IGF1R, hTERT and EWS-FLI1, are stabilized by HSP90. Exposure to PU-H71 resulted in depletion of AKT, ERK, MYC, C-kit, IGF1R ...

Translated from bench-to-bedside the Hsp90 inhibitor PU-H71 and the non-invasive companion diagnostic 124I-PU-H71 PET assay Doctors and faculty members often work with pharmaceutical, device, ...

These assays are based on our finding that PU-H71 and PU-AD specifically interact with the tumor HSP90-incorporating epichaperomes. We have developed a positron emission tomography-based assay that ...

H71, "The Vulnerable Child Protective Act" bans gender affirming care for minors in the state of Idaho and would bar transgender and transitioning children, or children with gender dysphoria, from ...

iFFALCON, TCL’s sub-brand is all set to launch its 2020 QLED TVs in India. The model numbers will be H71 and K71 series and are expected to have similar features found on TCL’s recently ...