DNA微珠能够灵活地在多种培养组织中运输不同的信号分子，为设计更复杂的类器官开辟了新途径。未来类器官模型可加速人们对多种疾病的模拟研究，进而带来疗效更好的药物或治疗方式。

Planarian flatworms regenerate their heads and tails after amputation. It turns out that they use Wnt–β-catenin signalling to determine where the head and the tail should form. Figure 1 ...

这表明，DNA微珠的注射和整合不会对类器官的正常发育产生显著影响。 在实验过程中，研究人员利用小型视网膜类器官模型进行了详细的时间分辨荧光显微成像实验，观察了Wnt替代物（Wnt-surrogate）的扩散过程。结果表明，Wnt替代物的扩散速度显著慢于对照组的 ...

We know today that Wnt and a handful of other signalling systems (Notch, Hedgehog, TGFβ (transforming growth factor-β)–BMP (bone morphogenetic protein) and receptor tyrosine kinases ...

2018年1月19日，南方医科大学萍乡医院 (萍乡市人民医院)泌尿外科在Medical Science Monitor (中科院四区 IF=2.2)刊上在线发表题为 "GP73 promotes invasion and metastasis of bladder cancer by regulating the epithelial-mesenchymal transition through ...

相反，在新的生发周期中，HFSCs在BMP抑制剂和WNT激活调控下从静息态转变为激活态。激活的HFSCs产生SOX9 + TCF3/4 + 和LEF1 + TCF1 + 两种干细胞群体。有意思的是，R-spondins（WNT激动剂）与atRA结合也能促进HFSCs由静息向激活转换，但所需atRA最优浓度要比维持静息的atRA最优 ...

A new review was published in Oncotarget's Volume 15 on August 2, 2024, entitled, “Targeting WNT5B and WNT10B in osteosarcoma ...

Although differentiation and activity of bone-forming osteoblasts are regulated at various levels, there is ample evidence ...

结直肠癌（CRC）是一种常见的恶性肿瘤，在所有癌症中的发病率（6.1%）位居第三，死亡率（9.4%）居第二位。由于大肠癌的 ...

研究成果以“肠源性记忆γδ T17细胞加重脓毒症所致急性肺损伤（Gut-derived memory γδ T17 cells exacerbate sepsis-induced acute lung injury）”为题，于2024年8月7日在线发表于《自然?通讯》（Nature Communications）杂志 图 “肠-肺轴”调控脓毒症诱导的急性肺损伤机制及潜在的 ...

Use precise geolocation data and actively scan device characteristics for identification. This is done to store and access ...

However, whether BCAS2 has other functions within the nucleus remains largely unknown. Here, we show that BCAS2 is essential for primitive hematopoiesis in zebrafish and mouse embryos. The activation ...