A retrovirus with an RNA genome, which is copied into DNA by a reverse transcriptase, is prone to mutations because the enzyme lacks the 3’ to 5’ proofreading capability of DNA polymerases. Scientists ...

Mother-to-child transmission often led to pretreatment drug resistance and acquired drug resistance in children living with ...

New England Biolabs (NEB®) announced today that they have released a novel, thermostable reverse transcriptase, WarmStart® RTx Reverse Transcriptase, specifically designed for nucleic acid detection.

They do this by blocking an enzyme called reverse transcriptase that helps HIV make copies of itself. There are several FDA-approved NRTIs. They include: Abacavir (Ziagen) Emtricitabine (Emtriva) ...

The crystal structure of a human endogenous reverse transcriptase has similarities to HIV reverse transcriptase, a well-known tractable drug target, which will help design drugs to treat cancer ...

In addition to uncovering abbreviated versions of LINE1, the scientists found that most of these variations contained only one of the two protein-coding regions that appear on a full-length ...

Read the latest data on resistance associated with reverse transcriptase inhibitors in these summaries from the 12th International HIV Drug Resistance Workshop.

The risk of Alzheimer’s decreased by 6% to 13% for each year the patients were on nucleoside reverse transcriptase inhibitors. Atthapon – stock.adobe.com ...

New research shows a transcriptase that helps time cell death varies in expression, and is unusually localized, in cancer cells. The transcriptase, Telomerase Reverse Transcriptase (TERT), is ...

The World Health Organization recommends dolutegravir with two nucleoside reverse-transcriptase inhibitors (NRTIs) for second-line treatment of human immunodeficiency virus type 1 (HIV-1) infection ...

Nucleoside Reverse Transcriptase Inhibitors (NRTIs) and Nucleotide RTIs (NtRTIs) NRTIs are prodrugs that require intracellular modification to active NRTI-triphosphates using the kinases of host ...