Brain metastases represent an important cause of morbidity in patients with lung cancer and are associated with a mean survival of less than 6 months. Thus, new regimens improving the outcome of ...

Patients with SCLC previously treated with platinum-containing chemotherapy were randomly assigned to receive amrubicin (40 mg/m 2 on days 1 through 3) or topotecan (1.0 mg/m 2 on days 1 through 5).

Investigators randomly assigned 119 patients to IV topotecan (Hycamtin, GlaxoSmithKline) 2 mg/m 2 daily for 5 days or IV topotecan 0.75 mg/m 2 daily plus cyclophosphamide 250 mg/m 2 daily for 5 days.

Lurbinectedin superior to topotecan in platinum-resistant ovarian cancer Overall response rate (ORR), the primary endpoint together with safety, was 22% with lurbinectedin and 0% with topotecan.

Topotecan's time has passed. "Topotecan's time has passed. There is not a better schedule or dose scheme out there to try," Dr. Hoskins told Medscape Medical News.

Adding topotecan to carboplatin plus paclitaxel, the standard treatment for ovarian cancer, does not improve progression-free survival in patients and leads to greater toxicity, according to a ...

St. Jude Children's Research Hospital researchers report a topotecan-based chemotherapy regimen should be considered front-line therapy for patients with advanced bilateral retinoblastoma; an eye ...

Adding topotecan to carboplatin plus paclitaxel, the standard treatment for ovarian cancer, does not improve progression-free survival in patients and leads to greater toxicity, according to a ...

Ovarian cancer - topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for advanced recurrent disease only (Review of TA 91): NICE response to consultee and ...