High expression of thymidylate synthase (TS) and inactivation of p53 are allegedly associated with chemoresistance. The authors evaluated TS and p53 expression in gastric cancer treated with ...

编辑推荐： 来自台湾阳明大学，台湾大学的研究人员发表了题为“Tumor Cells Require Thymidylate Kinase to Prevent dUTP Incorporation during DNA Repair”的文章，指出了癌细胞在DNA修复过程中需要胸苷激酶，来阻止dUTP的掺入，这说明了胸苷激酶对于癌细胞DNA修复的重要性，也表明了针对这种作用因子的抑制剂，也许 ...

Is thymidylate synthase a reliable predictor for response and survival during hepatic arterial infusion for hepatic metastases from colorectal cancer?. Br J Cancer 95, 1304–1305 (2006). https ...

Purpose: To investigate the role of thymidylate synthase (TS), p53, and epidermal growth factor receptor (EGF-R) expressions in hepatic tumors in predicting overall survival (OS), progression-free ...

Tumor genotyping (frequency of allelic loss, 26%) showed that the 3R/3R genotype was associated with a better outcome (hazard ratio [HR] = 0.38; 95% CI, 0.16 to 0.93; P = .020 for the recessive model) ...

Thymidylate synthase (TS) is a substance that the body produces naturally. Cancer cells need TS to be able to copy their DNA before they divide into 2 new cells. Researchers think that treatment for ...

The viability of parasitic protozoa is severely diminished by imparing thymidylate (dTMP) biosynthesis. The absence of enzymatic activities which are specifically involved in the formation of dTMP ...

The presence of dUMP in DNA from cells treated with methotrexate is a result of the great increase in intracellular concentration of dUTP and the fall in dTTP that accompany inhibition of thymidylate ...