Chemotherapeutic agents targeting thymidylate biosynthesis, and particularly the enzyme thymidylate synthase, have now been key cancer therapies for 60 years. In this article, the classic and ...

来自台湾阳明大学，台湾大学的研究人员发表了题为“Tumor Cells Require Thymidylate Kinase to Prevent dUTP Incorporation during DNA Repair”的文章，指出了癌细胞在DNA修复过程中需要胸苷激酶，来阻止dUTP的掺入，这说明了胸苷激酶对于癌细胞DNA修复的重要性，也表明了针对这种作用因子的抑制剂，也许能用于癌症 ...

Conventional thymidylate synthases, including the human enzyme, use an active site amino acid side-chain to activate the substrate at this stage of the reaction.

A number of studies have investigated the relationship between thymidylate synthase (TS) expression and survival in colorectal cancer (CRC) patients. Although most have reported poorer overall and ...

The viability of parasitic protozoa is severely diminished by imparing thymidylate (dTMP) biosynthesis. The absence of enzymatic activities which are specifically involved in the formation of dTMP ...

Purpose: To investigate the role of thymidylate synthase (TS), p53, and epidermal growth factor receptor (EGF-R) expressions in hepatic tumors in predicting overall survival (OS), progression-free ...

Donald D. Anderson, Cynthia M. Quintero, Patrick J. Stover, Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria, Proceedings of the National Academy of Sciences of ...

Thymidylate synthase (TS) is a substance that the body produces naturally. Cancer cells need TS to be able to copy their DNA before they divide into 2 new cells. Researchers think that treatment for ...

The paper titled ‘ Germline thymidylate synthase deficiency impacts nucleotide metabolism and causes dyskeratosis congenita ’ was published in The American Journal of Human Genetics on Friday 5 August ...