Telomeric mononucleosomes have been found to be hardly detectable in such experiments since they are highly sensitive to overdigestion with micrococcal nuclease. 23 These results clearly show that ...

Two studies report expression of telomeric-repeat-containing RNAs in vertebrates. This discovery challenges the long-standing notion that telomeres are transcriptionally inert.

As described by Xin et al., in Genome Biology in 2008, telomeres are nucleoprotein structures at the ends of eukaryotic chromosomes. These structures help maintain eukaryotic genome integrity by ...

By using a DNA probe that specifically hybridizes to the telomeric region of human chromosomes, we were able to test this assertion directly. After scanning more than 200 dicentrics produced in normal ...

Jayakrishnan Nandakumar, Elaine R. Podell, Thomas R. Cech, Titia de Lange, How Telomeric Protein POT1 Avoids RNA to Achieve Specificity for Single-Stranded DNA, Proceedings of the National Academy of ...

Newly discovered telomeric protein VR, (green spheres) is seen accumulating in nuclei (blue ovals) in human osteosarcoma cancer cells stained in red. [Griffith Lab, UNC Lineberger] ...

SARS-CoV-2 causes the pandemic coronavirus disease COVID-19, that is more harmful for elderly people, who show more severe symptoms and are at higher risk of hospitalization and death.

Telomeric repeat-containing RNA (TERRA) constitutes a nucleoprotein component of extracellular inflammatory exosomes. Proceedings of the National Academy of Sciences, 2015; 201505962 DOI: 10.1073 ...

In normal mammalian cells, a small telomeric DNA segment is lost after each cell cycle, gradually eroding to a critical length. At this point, DNA repair systems recognize it as DNA damage and trigger ...

Scheme representing the telomeric elongation process associated with the cell division of pluripotent cells and the generation of animals with hyper-long telomeres. Mouse embryonic stem cells are ...

They conducted experiments – as described in the PNAS paper – to show how telomeric DNA can instruct the cell to produce signaling proteins they termed VR (valine-arginine) and GL (glycine ...

There is a need regarding cardiovascular disease and heart failure for a therapy that reverses the progression of ventricular dysfunction. Previous findings have shown that cardiomyocytes during ...