Telomeric mononucleosomes have been found to be hardly detectable in such experiments since they are highly sensitive to overdigestion with micrococcal nuclease. 23 These results clearly show that ...

In normal mammalian cells, a small telomeric DNA segment is lost after each cell cycle, gradually eroding to a critical length. At this point, DNA repair systems recognize it as DNA damage and trigger ...

Interestingly, the distribution of DNA breaks causing telomeric allelic imbalance didn’t appear to be random, as many were located in close proximity to each other, the team notes.

The structure of TPP1's oligonucleotide binding fold contains features that are particularly characteristic of TEBPβ. When the POT1–TPP1 complex is bound to telomeric DNA, it does not inhibit ...

As described by Xin et al., in Genome Biology in 2008, telomeres are nucleoprotein structures at the ends of eukaryotic chromosomes. These structures help maintain eukaryotic genome integrity by ...

They conducted experiments – as described in the PNAS paper – to show how telomeric DNA can instruct the cell to produce signaling proteins they termed VR (valine-arginine) and GL (glycine ...

Jayakrishnan Nandakumar, Elaine R. Podell, Thomas R. Cech, Titia de Lange, How Telomeric Protein POT1 Avoids RNA to Achieve Specificity for Single-Stranded DNA, Proceedings of the National Academy of ...

SARS-CoV-2 causes the pandemic coronavirus disease COVID-19, that is more harmful for elderly people, who show more severe symptoms and are at higher risk of hospitalization and death.

Telomeric repeat-containing RNA (TERRA) constitutes a nucleoprotein component of extracellular inflammatory exosomes. Proceedings of the National Academy of Sciences, 2015; 201505962 DOI: 10.1073 ...

More information: Yu-Hung Hsieh et al, Telomeric repeat-containing RNA increases in aged human cells, Nucleic Acids Research (2025). DOI: 10.1093/nar/gkaf597 ...

Scheme representing the telomeric elongation process associated with the cell division of pluripotent cells and the generation of animals with hyper-long telomeres. Mouse embryonic stem cells are ...

There is a need regarding cardiovascular disease and heart failure for a therapy that reverses the progression of ventricular dysfunction. Previous findings have shown that cardiomyocytes during ...