Meiotic crossover formation between homologous chromosomes (homologues) entails DNA double-strand break (DSB) formation, homology search using DSB ends, and synaptonemal-complex formation coupled ...

山东大学生殖医学研究中心陈子江教授团队联合香港大学的Kui Liu教授、武汉大学基础医学院的罗孟成教授以及中国科学院生物化学与细胞生物学研究所的李劲松研究员等同事，本月在《Nucleic Acids Research》杂志发表了题为“SCRE serves as a unique synaptonemal complex fastener and is essential for ...

The synaptonemal complex (green) connect the two homologous chromosomes (purple). The organisation of the synaptonemal … [more] As observed more than a century ago by the first geneticists, crossovers ...

The synaptonemal complex is a ladder-like cell structure that plays a major role in the development of egg and sperm cells in humans and other mammals. "The structure of this complex has hardly ...

If this effect is blocked, there are serious consequences: the protein structure (synaptonemal complex) that forms between the homologous chromosomes can no longer be established. A tiny amount – less ...

Synaptonemal complexes reveal mutagen-induced effects in germ cell meiotic chromosomes. This study was aimed at characterizing relationships between damage to synaptonemal complexes and metaphase I ...

Enter the synaptonemal complex (SC), a zipper-like protein structure that lines up and anchors the two parental chromosomes together, end-to-end, to facilitate successful genetic exchanges.

Kari Stefansson CEO of deCODE genetics and Valgerdur Steinthorsdottir scientist at deCODE genetics and author of the paper, Variant in the synaptonemal complex protein SYCE2 associates with ...

The Drosophila synaptonemal complex forms between homologous chromosomes as two distinct layers that mirror each other. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of ...

Ding Hua Lee a,b,cd, Yu-Hsin Kao a, Jia-Chi Ku a, Chien-Yu Lin a, Robert Meeley e, Ya-Shiun Jan f, Chung-Ju Rachel Wang a,b,cg, The Axial Element Protein DESYNAPTIC2 Mediates Meiotic Double-Strand ...

Scientists have discovered an association between a variant in the synaptonemal complex protein, SYCE2, and pregnancy loss through the effects of recombination. An international collaboration led by ...