Sirolimus-eluting stents and paclitaxel-eluting stents, as compared with bare-metal stents, reduce the risk of restenosis. It is unclear whether there are differences in safety and efficacy between ...

A sirolimus loading dose was administered to 19 (56%) of 34 patients, median 6 (3–8) mg, followed by maintenance of 1–2 mg/day to target therapeutic trough levels between 4 and 12 ng/ml ...

We investigated sirolimus and mycophenolate mofetil (MMF) as GVHD prophylaxis in patients with advanced hematological malignancies receiving myeloablative hematopoietic cell transplantation (HCT ...

Sirolimus and paclitaxel-coated balloons showed comparable safety and effectiveness in treating CAD across diverse lesion ...

Sirolimus has been shown to reduce the occurrence of secondary skin cancers, but no study included a follow-up exceeding 2 years. We extended at 5 years the TUMORAPA randomized trial of ...

Sirolimus may be a safe and effective alternative for patients with chronic spontaneous urticaria who do not respond to other treatments, according to a study published in The Journal of Allergy ...

To test whether sirolimus, a drug approved for oral use in renal and cardiac transplantation, might also work in patients with ISR undergoing PCI, they tested two loading regimens against placebo.

After case reports of patients with renal AML and LAM responding to sirolimus were published, 11 – 13 Bissler et al 5 reported on treatment of 25 patients with AML or LAM with sirolimus for 12 months ...

Sirolimus was discontinued for adverse events in 9 of 50 (18%) children. The authors concluded that sirolimus and reduced-dose TAC might prevent rejection and spare renal function without ...

Source Reference: Finn AV "Sirolimus-coated balloons for in-stent restenosis: the evolution of PCI" Circ Cardiovasc Interv 2024; DOI: 10.1161/CIRCINTERVENTIONS.124.014464.

Editorial Efficacy of Sirolimus in Treating Tuberous Sclerosis and Lymphangioleiomyomatosis Authors: Elahna Paul, M.D., Ph.D., and Elizabeth Thiele, M.D., Ph.D. Author Info & Affiliations ...

Treatment with sirolimus led to durable complete responses in children with refractory multi-lineage autoimmune cytopenias, according to the results of a prospective multi-institutional trial.As ...