Silybin通过靶向Skp2对非小细胞肺癌有治疗作用 【字体： 大 中 小 】 时间：2022年08月08日 来源： 编辑推荐： 大量研究表明，SB也有很好的抗癌作用;然而，SB的抗癌靶点及其作用机制尚不清楚。

慢性肾脏病 (CKD)中肾纤维化缺乏有效治疗手段，铁死亡 (Ferroptosis)作为关键病理机制尚未明确。广州中医药大学团队发现水飞蓟宾 (Silybin)通过直接结合铁蛋白重链1 (FTH1)稳定铁代谢，显著抑制铁死亡和纤维化进展。该研究发表于《Phytomedicine》，为靶向上游铁代谢的抗纤维化治疗提供新策略。

Background: Silybin-phosphatidylcholine (Siliphos) is an orally bioavailable complex of silybin, a poorly absorbable polyphenolic flavonolignan derived from milk thistle and endowed with potential ...

Silybin A, aka silibinin A, is a natural product produced in the fruits of the two species of milk thistle: Silybum eburneum, which grows in Spain and northern Africa, and the more common S. marianum, ...

Chinese scientists have discovered the transport mechanism of lactate -- a critical metabolic fuel for cancer cells -- and screened out silybin, a natural compound that disrupts this pathway to ...

Silybin (SB), a natural flavonoid isolated from Silybum marianum, has been used to treat hepatic fibrosis in clinical settings and as a dietary supplement, because of its hepatoprotective potential.

Silybin binds precisely to the transporter's substrate pocket, disrupting MCT1 function and leading to toxic accumulation within cancer cells.

Addis Ababa, April 7, 2025 (ENA) -- Chinese scientists have discovered the transport mechanism of lactate -- a critical metabolic fuel for cancer cells -- and screened out silybin, a natural ...