“Overall, our study provides a proof-of-principle that human glia can be reprogrammed to cells that are capable of making new neurons,” said Thomas Reh, PhD, University of Washington.

Researchers have used reprogrammed CAR T cells, usually used as a cancer treatment, to target the senescent cells that contribute to aging and later-life diseases. After one treatment, old mice ...

The reprogrammed cells then begin to divide and form precursors for new neurons,” said Simon Anders, PhD, project group leader at Heidelberg and one of the lead researchers on the study.

Rejuvenate Bio systemically delivered AAVs (gene therapy delivered via altered virus shells), encoding an inducible OSK system, in 124-week-old mice extends the median remaining lifespan by 109% over ...

Partially reprogrammed stem-cell-like fibroblasts provide a solution. Their distinguishing feature is that they are undifferentiated, in a youthful state, so to speak.