The Bumble and bumble Reactivator takes my waves from flat and lifeless to bouncy, full, and defined. Now, I don’t have to worry as much about planning my showers and lengthy hair routine around ...

Organophosphorus compounds (OPs) include several types of chemical compounds used as pesticides, herbicides or nerve agents in chemical warfare that, once in the body, act by inhibiting ...

NTS-071, small-molecule p53 Y220C reactivator with excellent antitumor efficacy in vivo Nov. 15, 2024 ...

On April 23, 2025, Nutshell Therapeutics ( Shanghai ) Co., LTD. received IND clearance from the FDA to initiate Phase 1 clinical trial in the United States for its NTS071, a novel small molecule ...

IND Application for NTS071, Nutshell Therapeutics' p53 Y220C Allosteric Reactivator, Received US FDA clearance Provided by PR Newswire May 4, 2025, 6:48:00 AM ...

Effectiveness of "reactivator" therapy was followed by serial cholinesterase assays. A portion of the 2-PAM iodide used in the therapy was isotope labeled, and its concentration in the blood and ...

NTS071 is an oral small molecule allosteric reactivator targeting p53 Y220C with a novel scaffold. It selectively binds to the p53 Y220C mutant protein, improving its thermal stability, thereby ...

APR-548, a next-generation small molecule reactivator of mutant p53, is being developed for oral administration. For more information, please visit the company website at www.aprea.com.