Pyrogens and Parenteral PharmaceuticalsEndotoxin, also called lipopolysaccharide (LPS), is composed of hydrophobic fatty acid and hydrophilic carbohydrate domains. The primary hydrophobic domain, also ...

Cytokines are pleiotropic molecules mediating several pathologic processes. Long before the discovery of cytokines as immune system growth factors or as bone marrow stimulants, investigators learned a ...

Monocyte activation test (MAT) Molecules it detects: Many pyrogens Microbial sources of those molecules: Gram-negative bacteria, gram-positive bacteria, fungi, and viruses Source: Lonza.

Our ability to demonstrate effective depyrogenation by rinsing is hampered by the materials and processes we use. Manufacturers must use methods that remove pyrogens efficiently and ensure patients’ ...

The Union health ministry has issued draft notification to amend the Drugs and Cosmetics Rules, 1945 to bring in several changes including inclusion of bacterial endotoxins in the testing requirements ...

Pune, April 11, 2022 (GLOBE NEWSWIRE) -- Monocyte activation test based on the reaction of human monocytes, now allows predicting the human response to all pyrogens (i.e. endotoxin and non ...

When the infection subsides, pyrogens decrease and the hypothalamus resets the temperature. You sweat, your blood vessels dilate, and you cool off. You’re feeling better.