MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by NF1 loss in Schwann cells and skeletal stem/progenitor cells Journal: Science Translational Medicine Published: 2024-06-26 DOI: ...

Researchers found pseudarthrosis (lack of new bone regrowth) to be five times more likely after a polyetheretherketone (PEEK) interbody spacer device had been used to bridge the gap between ...

The authors found radiographic evidence of pseudarthrosis in 29 (52%) of the 56 patients with PEEK implants and in 7 (10%) of the 71 patients with structural allografts.

Novadip’s pipeline includes two lead products: NVD003, an autologous cell-based therapy currently in phase 1b/2a clinical trials in adults with bone non-union, and pediatric congenital pseudarthrosis ...

The researchers found that diagnosing pseudarthrosis following cervical and lumbar fusion remains a challenge. A diagnosis is typically made based on clinical presentation in conjunction with ...

The prospective study conducted at 10 centers across the U.S. analyzed a total of 142 patients with one or more risk factors for pseudarthrosis.

Our therapy, a combination of demineralized bone with gene therapy, is a promising solution for the currently existing complication problems in pseudarthrosis and other bone defects and fracture ...

The pseudarthrosis rate was 28.1% in the ICBG group compared with 6.4% in the BMP group. “The difference in ‘pseudo’ rate was statistically significant (P =0.04),” Kim said.

Overall, the rate of symptomatic pseudarthrosis was 1.9% in the BMP group and 1.4% in the control group. The researchers noted BMP use during the procedure was associated with a 44% increased risk ...