乳腺癌（BC）发病率和死亡率逐年上升，转移是患者预后差和死亡主因，骨转移尤为突出。Ras-proximate-1（RAP1）在 BC 等疾病中上调且影响肿瘤转移，但相关研究较少。本文综述 RAP1 在 BC 骨转移中的致病作用、相关信号通路及调节 BC 骨转移的天然化合物，为防治 BC 骨转移提供新思路。

Leaders who are proximate are not just good for upfront input, after-the-fact feedback, or even engagement throughout. Proximate leaders should be leading, not following, the field’s cadre of academic ...

Carbohydrate, lipid, and protein compositions are stoichiometrically related to organic CHN (carbon, hydrogen, nitrogen) contents. Elemental CHN analyses of total biomass and ash, therefore, provide a ...

With just 47 seconds left in the fourth quarter of Game 2 of the 2024 Western Conference Finals, the Dallas Mavericks trailed the Minnesota Timberwolves, 108-106, and Minnesota’s Jaden McDaniels ...

A framework for analyzing the relationship between intermediate fertility variables and fertility levels is presented. An intermediate fertility variable is defined as any behavioral or biological ...

Courts are simply wrong when they suggest that proximate causation is an element of a breach of contract action—that the New York Court of Appeals makes clear enough in 34-0673, LLC v.

Although proximate cause often involves issues of fact that cannot be decided as a matter of law, New York courts regularly and closely scrutinize allegations that are speculative in nature. For ...