We tested a proposal that postsynaptic calcium and metabotropic glutamate receptors (mGluRs) are involved in the induction of hippocampal mossy fiber long-term potentiation (LTP)1. We found that ...

Postsynaptic locus of TRPV1 function in NAc D2+ MSNs In most brain structures, including the NAc, CB1 receptors are presynaptic and modify transmitter release 18.

Summary: New research uncovers how tau pathology spreads and damages synapses in progressive supranuclear palsy (PSP). Using ...

A research group led by Specially appointed professor, Dr. Tatsuo Suzuki of Shinshu University's School of Medicine developed a new purification protocol for Postsynaptic density (PSD) lattice, a ...

Differences in postsynaptic plasticity Postsynaptic density (PSD) is an extremely large multi-protein complex that is responsible for positioning signaling molecules that potentiate both the long ...

These events evoke the depolarization of the postsynaptic membrane, inducing transmission of a signal. N-methyl D-aspartate (NMDA) is one of the most common types of glutamate ionotropic receptors.

Richard R. Neubig, Elizabeth K. Krodel, Norman D. Boyd, Jonathan B. Cohen, Acetylcholine and Local Anesthetic Binding to Torpedo Nicotinic Postsynaptic Membranes after Removal of Nonreceptor Peptides, ...

(4) The neurotransmitters bind to receptor sites on ion channels in the postsynaptic membrane, causing them to open. (5) Ions flow into the postsynaptic neuron, which generates an action potential ...

Decades-old assumptions about brain plasticity upended Date: June 3, 2025 Source: University of Pittsburgh Summary: Your brain doesn t just send messages through one universal route it uses ...

Unfortunately, antidepressants also may bind themselves directly to postsynaptic receptors that confer side effects. Such receptors include histaminergic H 1, muscarinic, H 1 -adrenergic, and ...