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生物通
2月
RNA关联CRISPR筛选技术ReLiC揭示人类细胞转录后调控网络 ...
RNA分子在细胞中经历精密的代谢调控舞蹈,数千种RNA结合蛋白共同参与这场生命活动交响乐。研究者开发的ReLiC(RNA-linked CRISPR)技术像一把分子手术刀,通过将Cas9、sgRNA和条形码报告基因整合到特定基因组位点,系统解剖了2,092个人类RNA相关基因的功能谜团。 当这项技术与多核糖体(polysome)分级 ...
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