We performed a meta-analysis in an effort to systematically explore the association between apolipoprotein E (ApoE) ɛ2/ɛ3/ɛ4 polymorphisms and hypertension. We searched for case–control ...

Common single-nucleotide polymorphisms (SNPs) that are associated with blood low-density lipoprotein (LDL) or high-density lipoprotein (HDL) cholesterol modestly affect lipid levels. We tested the ...

This review presents the latest evidence on the link between genetic single nucleotide polymorphisms and dental caries, ...

Effects of Genetic Polymorphisms on the Pharmacokinetics of Calcineurin Inhibitors Kyle N. Utecht; Jon J. Hiles; Jill Kolesar Disclosures Am J Health Syst Pharm. 2006;63 (23):2340-2348. 0 ...

Background Athlete's heart as an adaptation to long-time and intensive endurance training can vary considerably between individuals. Genetic polymorphisms in the cardiological relevant insulin-like ...

Clopidogrel is a prodrug that requires biotransformation to an active metabolite by cytochrome P-450 (CYP) enzymes (Figure 1 in the Supplementary Appendix, available with the full text of this ...

Malgorzata Kowalczyk, Aleksander Owczarek, Renata Suchanek, Monika Paul-Samojedny, Anna Fila-Danilow, Paulina Borkowska, Krzysztof Kucia, Jan Kowalski, Heat shock protein 70 gene polymorphisms are ...

The anti–HER-2/ neu monoclonal antibody trastuzumab has been shown to engage both activatory (fragment C receptor [FcγR]IIIa; FcγRIIa) and inhibitory (FcγRIIb) antibody receptors and FcγR ...

Abstract 2065 Background: The carboxylesterase 2 (CES2) is a key enzyme for irinotecan bioactivation. The aims of this work were i) to search for genetic polymorphisms in promoter, coding sequence and ...

Maternal phylogenies estimated by restriction fragment length polymorphisms (RFLPs) in the chloroplast DNA (cpDNA) delineated a well-supported clade containing Allium altaicum, A. cepa (bulb onion), A ...

Single nucleotide polymorphisms (SNPs) are variations in a genome’s base pair in a DNA sequence, and occur in approximately 1 out of 800 base pairs. These occur when a single nucleotide is ...