Special Article Published: 14 February 2013 How can polygenic inheritance be used in population screening for common diseases? Muin J. Khoury MD, PhD, A. Cecile J.W. Janssens PhD & David F ...

Cite this article Chhibber, A., Mefford, J., Stahl, E. et al. Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).

Opinions differ as to the value of genetic information in the form of polygenic scores and the usefulness of polygenic score analysis as part of routine healthcare – clinical utility. Views on ...

Use of an Alzheimer’s disease polygenic risk score to identify mild cognitive impairment in adults in their 50s. Molecular Psychiatry, 2018; DOI: 10.1038/s41380-018-0030-8 ...

Cancer is a major health problem, and new approaches to predicting, preventing and treating this disease are being investigated all the time. It is also a complex disease, as a person’s environment, ...

Discussion The hypothesis of polygenic inheritance to account for the tendency to calcium oxalate stone formation implies that at least two (and probably more) gene loci influence susceptibility.

Investigators recorded the association between low (T1), medium (T2) and high (T3) polygenic scores within each self-reported racial and ethnic group to seven documented survival outcomes: overall ...

Today, polygenic scores are a blunt instrument for predicting disease risk. Down the road, combining them with other clinical factors and measures of disease risk will make them more effective.

Key takeaways: A polygenic risk score that includes rare variants did not substantially improve osteoporosis or fracture risk prediction. More data are needed for people of non-European ancestry ...

Developing a polygenic risk score makes sense to Zhao. The estimated inheritance or familial risk for POAG was 9.4% in a 2021 study in which researchers identified 127 significant associated ...

More than 216 scientific papers on polygenic risk scores were published last year. The idea also made our 2018 list of 10 Breakthrough Technologies. To build its diabetes predictor, 23andMe says ...

In polygenic inheritance, a specific trait is affected by many genes. Wolves display polygenic inheritance in their running speed. Suppose that running speed is determined by the additive contributing ...