Made up of amino acids, SARS-CoV-2's polybasic cleavage sites have remained elusive since the COVID-19 outbreak began. But previous research indicates that these mysterious sites are essential for ...

A computer model showing the polybasic cleavage sites, located on the novel coronavirus' protein spike. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases ...

Ultimately, Peacock and colleagues have observed that furin CS SARS-CoV-2 viruses are able to transmit much faster than variants with deleterious mutations that lack this polybasic ability.

Overall, the study findings highlighted the waning of BNT162b2 vaccine efficiency with the inability to neutralize the Omicron variant and the importance of the P681 polybasic position within the ...

The team saw signs of natural selection acting on key coronavirus genome features such as the receptor-binding domain (RBD) sequences and sequences spanning so-called "polybasic cleavage sites ...