本研究针对骨肉瘤 (OS)高复发率与不良预后的临床难题，首次揭示传统中药Cyclocarya paliurus主要活性成分阿江榄仁酸 (AA)通过靶向Wnt3a信号轴调控肿瘤相关巨噬细胞 (TAMs)极化，抑制M2型巨噬细胞分化并促进促炎性M1表型转化，从而显著抑制OS细胞增殖、迁移和侵袭。该发现为开发基于肿瘤微环境 (TME)调控 ...

Cyclocarya paliurus polysaccharide treatment increased the beneficial bacteria genus Ruminococcaceae UCG-005 which was reported to be a key genus for protecting against diabetes.