Osteoblastic syndecan-2 affected osteogenic precursor apoptosis. RT-qPCR analysis of mRNA expression of Bcl2 (a) and BAX (b) in BMCs or bone extracts from 4-month-old mice.

The osteoblastic differentiation of HBMSC culture was evaluated by measuring cellular alkaline phosphatase (ALP) activity and calcium deposition, as well as osteoblastic markers by real-time RT-PCR.

Antagonizing exosomal miR-18a-5p derived from prostate cancer cells ameliorates metastasis-induced osteoblastic lesions by targeting Hist1h2bc and activating Wnt/β-catenin pathway.

Downregulation of PTHrP and RANKL inhibited osteoclastogenesis and proliferation of stromal/osteoblastic cells. Release of TGF-a and IGF from the bone matrix was blocked. Vinorelbine destabilized MT ...

Osteoblastic lesions were seen in 23% of the cases, and they all showed different patterns.

The authors further reported that among the 32 patients included in the study, 25 were classified into the osteoblastic group, with a mean age of 73 ± 6.6 years, while the remaining 7 were placed ...

Morphology of bone metastases was osteolytic, osteoblastic and mixed in 32%, 25% and 22% of cases, respectively, with 21% of cases of unknown morphology.