Oligonucleotides are short, single-stranded DNA or RNA molecules, typically composed of 13 to 25 nucleotides. They are the fundamental building blocks of nucleic acids and play a crucial role in ...

The poster, “Intracellular Delivery of Small Oligonucleotides with Lipid Nanocrystals (LNCs): in vitro studies,” was presented by Hui Liu, PhD, Chief Technology Officer of Matinas, and is ...

When LINE-1 RNA was depleted in human progeroid cells using antisense oligonucleotides the senescent phenotypes were ameliorated, while in the premature aging mouse model this therapy restored tissue ...

Cleavage of oligonucleotides is the process of removing the oligonucleotide from a solid support. The traditional batch method involves heating an aqueous solution of ammonia or methylamine, or a ...

Oligonucleotides for molecular and therapeutic applications require high resolution purity analysis, as well as identification and quantification of their structural impurities.

This article from Merck explains how oligonucleotides are being delivered by multifunctional blockcopolymers - a form of "smart" delivery.

News Animal models Antisense oligonucleotides Biological therapy Brain cancer Cancers Clinical trial Congenital and neonatal abnormalities Disease models Drug research and development Gene therapy ...

Antisense oligonucleotides (ASO) hold great promise for pharmacotherapy. Now, researchers at Tokyo Medical and Dental University (TMDU) and Ionis Pharmaceuticals, advancing their earlier work on a ...

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And customers in Europe and US was asking us to build these complex APIs, peptides, oligonucleotides. Now, for example, we're using asymmetric hydrogenation to selectively reproduce chiral molecules ...