Oligonucleotides, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are increasingly being used in diagnostics and therapeutics. For instance, DNA can be introduced into immune cells ...

More information: Dmitry D. Zhdanov et al, Inhibition of telomerase activity by splice-switching oligonucleotides targeting the mRNA of the telomerase catalytic subunit affects proliferation of ...

Practical solutions to purification and analytical challenges in PDC manufacturing, along with insights into synthesizing complex peptides, oligonucleotides, and conjugates.

Article Published: May 2000 Reversal of epidermal hyperproliferation in psoriasis by insulin-like growth factor I receptor antisense oligonucleotides Christopher J. Wraight, Paul J. White, Sandra ...

Summary The leading CDMO in peptides and oligonucleotides manufacturing, Bachem, has started building a new future for oligonucleotides: solving the industry’s main challenges around capacity, ...

Oligonucleotides for molecular and therapeutic applications require high resolution purity analysis, as well as identification and quantification of their structural impurities.

When LINE-1 RNA was depleted in human progeroid cells using antisense oligonucleotides the senescent phenotypes were ameliorated, while in the premature aging mouse model this therapy restored tissue ...

And customers in Europe and US was asking us to build these complex APIs, peptides, oligonucleotides. Now, for example, we're using asymmetric hydrogenation to selectively reproduce chiral molecules ...

Founded in 1996, TriLink develops and manufactures oligonucleotides, mRNA transcripts, nucleotides, bioconjugation, custom chemistry, solutions for PCR & RT-PCR, and NGS library preparation kits.

Oligonucleotides are nucleic acid strings synthesized by linking phosphoramidites. They are the basis of therapies with names like antisense and small interfering RNA (siRNA) that work by ...