NOXA过表达加剧PERK依赖性损伤 构建NOXA过表达载体 (OE-NOXA)后，NPCs出现与TG处理相似的凋亡和ECM降解表型。 PERK抑制剂GSK2606414能部分逆转这些效应，证实NOXA通过PERK通路发挥作用。 NOXA敲降缓解IVDD病理进程 ...

NOXA is a pro-apoptotic member of the BCL-2 family, which mediates induction of apoptosis via activation of mitochondria and the intrinsic apoptosis signaling pathway. 1, 2 Cell death induction by ...

Background: PUMA and NOXA are two pro-apoptotic members of the BH3-only subgroup of the BCL-2 family. These two proteins play a role in the initiation of apoptosis. The objective of this study is to ...