Abnormal microglial energy metabolism in AD. Translocation of Aβ into microglial mitochondria by the outer membrane translocase (TOM) impairs mitochondrial function and inhibits phagocytosis.

Certain subsets of microglia were found to be enriched in nervous system tissues from people with amyotrophic lateral ...

Researchers examined 152,459 microglial transcriptomes from 443 individuals, identifying 12 transcriptional states and their relationship to Alzheimer's disease.

Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies. Nature Genetics, 2022; DOI: 10.1038/s41588-021-00976-y ...

Tiziana Life Sciences, Ltd. (Nasdaq: TLSA) (“Tiziana” or the “Company”), a biotechnology company developing breakthrough immunomodulation therapies with its lead development candidate, intranasal ...

More information: Qiudan Luo et al, The interaction between microglial dysfunction and mitochondrial impairment in Alzheimer's disease, Aging Research (2024). DOI: 10.26599/AGR.2023.9340020 ...

The FDA has given the green light for Tiziana Life Sciences’ IND to advance its Phase IIa study of intranasal foralumab for ...

"Regulating microglial activity may reduce inflammation in neurodegenerative diseases." ScienceDaily. ScienceDaily, 17 October 2018. <www.sciencedaily.com / releases / 2018 / 10 / 181017111016.htm>.

All authors read and approved the final manuscript. Cite this: Apigenin and Luteolin Modulate Microglial Activation Via Inhibition of STAT1-Induced CD40 Expression - Medscape - Sep 25, 2008.

Abstract Primary rodent astroglial-enriched cultures are the most popular model to study astroglial biology in vitro. From the original methods described in the 1970's a great number of minor ...