撰文丨王聪编辑丨王多鱼排版丨水成文在全身造血干细胞/祖细胞移植（HCT）后，移植的同种异体髓系细胞会向大脑迁移，作为治疗手段来纠正脑部遗传缺陷（例如溶酶体贮积症）具有巨大前景。然而，同种异体造血干细胞/祖细胞移植前，需要进行骨髓消融（myeloabl ...

Dysregulated lipid metabolism in Alzheimer’s disease causes lipid buildup in microglia, reducing the immune cell’s ability to ...

Tay-Sachs and Sandhoff diseases, genetic disorders affecting the brain, have no effective treatment and are typically fatal ...

Study links early smell loss in Alzheimer’s to immune cells removing key brain fibers, suggesting potential for early ...

In early Alzheimer's disease, the brain's immune system fatally attacks neuronal fibers crucial for the perception of odors.

A fading sense of smell may be one of the earliest warning signs of Alzheimer’s disease, and new research reveals why.

Without the receptor, ADGRG1, the microglia barely nibbled on the toxic protein. Using a mouse model of Alzheimer's disease, the researchers observed how the loss of ADGRG1 led to the rapid buildup of ...

Brain’s immune cells may explain why a fading sense of smell is an early signal for Alzheimer's disease even before cognitive ...

Certain subsets of microglia were found to be enriched in nervous system tissues from people with amyotrophic lateral ...

Pyramidal neuron subtype diversity governs microglia states in the neocortex. Nature, 2022; DOI: 10.1038/s41586-022-05056-7 ...