Senescent macrophages have been overlooked for too long. They're not just passive markers of aging—they actively reshape the ...

The tumor microenvironment (TME) represents a highly complex system that encompasses cellular components (such as cancer cells, stromal cells, and immune cells) and non-cellular components (such as ...

The tumor microenvironment (TME) is a critical factor in antitumor immunity and treatment outcome in cancer therapy. We have developed an analysis tool called the immuno-oncology biological research ...

This review elucidates the dysfunction of B cells in tumor microenvironment, summarizes the discovery and mechanism of action of B cell ICs in tumors, and discusses urgent issues and future ...

Targeted cancer drugs known as CDK4/6 inhibitors have improved outcomes for patients with advanced or metastatic HR+/HER2- breast cancer, but many patients still eventually relapse and become ...

Blocking a key metabolic enzyme helps B cells fight liver tumors, revealing a new immunotherapy pathway for fatty liver–driven cancer in mice.

The tumor microenvironment (TME) is a complex and dynamic ecosystem crucial for cancer progression and therapeutic response. Tumors actively shape this ...

Title: Results from a Phase 1 expansion cohort of solnerstotug (pH-selective anti-VISTA antibody) combined with cemiplimab in patients with advanced solid tumors resistant to prior PD- (L)1 therapy ...

The tumor microenvironment is home to a raft of distinct components, signaling pathways, and more. To understand the microenvironment is to understand how to better treat cancer. This article from ...

Characteristics of the tumor microenvironment are likely to contribute to the aggressiveness of triple-negative breast cancer (TNBC) and the extremely poor prognosis of those who suffer it. By ...