Mast cell‐derived serotonin enhances methacholine‐induced airway hyperresponsiveness in house dust mite‐induced experimental asthma. Allergy, 2021; DOI: 10.1111/all.14748 ...

When methacholine binds M3, the mast cells release serotonin. This then acts on nerve cells, which in turn control the airways.

Cite this: Aaron B. Holley. Recommended Changes to Methacholine Challenge Testing May Be Difficult to Apply for Most Labs - Medscape - Mar 15, 2019.

Background Methacholine hyperresponsiveness is prevalent in elite athletes. Comparative studies have hitherto been limited to methacholine, eucapnic voluntary hyperpnoea and exercise. This study ...

Peripheral airway response to methacholine was similar among obese adults with and without asthma, although forced expiratory volume was lower for those with asthma, based on data from 53 ...

Allergen and methacholine immediately induced similar levels of bronchoconstriction. Eosinophilic inflammation of the airways increased only in the allergen group, whereas both the allergen and ...

Britt-Marie Sundblad, Britt-Marie Larsson, Fernado Acevedo, Lena Ernstgård, Gunnar Johanson, Kjell Larsson, Lena Palmberg, Acute respiratory effects of exposure to ammonia on healthy persons, ...

Response to methacholine There were no significant differences in the maximal response to methacholine between obese and non-obese subjects measured by the % fall in FEV 1 (P =0.80) or sGrs (P =0.62).

Methacholine had less troublesome side effects than histamine, but hypotension, salivation, nasal congestion, flushing, tachycardia and sweating were commonly noted.

The administration of a two-tiered methacholine challenge test is an accurate, time-saving method that also avoids decreased forced expiratory volume in 1 second, according to results from a ...