Pasithea completes enrollment and initial dosing of first Cohort from its phase 1/1b trial of PAS-004 in adult NF1 patients: Miami Saturday, August 2, 2025, 18:00 Hrs [IST] Pasith ...

Macrocyclic drugs are an emerging class of therapeutics that promise to open up drug target spaces which are poorly addressed by small chemical entities and larger biologics. Cyclosporin is the ...

Macrocyclic peptides are promising candidates for pharmaceuticals, but their screening is difficult. Scientists have now developed an easy-to-use, high-throughput screening assay for cyclic ...

New cyclization reactions for synthesizing macrocyclic drug leads Date: August 21, 2019 Source: Ecole Polytechnique Fédérale de Lausanne Summary: Scientists have developed a new method to ...

The macrocyclic, extra-cellular – or general-purpose – manganese-based contrast agent has comparable relaxivity - the ability of a contrast agent to enhance signal intensity during an MRI scan ...

“Macrocyclic peptides are opening up a new modality, one that merges the best attributes of biologics and small molecules to drug targets that were once considered out of reach,” said Pye. “argenx has ...

CHALFONT ST GILES, England--(BUSINESS WIRE)--The U.S. Food and Drug Administration (FDA) has approved Clariscan™, a macrocyclic, ionic, gadolinium-based, MRI contrast agent, expanding the GE ...

Hepatocyte growth factor (HGF) is involved in cancer progression through MET receptor signaling. Here, HiP-8, a 12 amino-acid macrocyclic peptide, was identified to selectively recognize active ...

The Food and Drug Administration (FDA) has approved 2 new macrocyclic gadolinium-based contrast agents (GBCAs), Elucirem ™ (gadopiclenol) and Vueway ™ (gadopiclenol), for use with magnetic ...

Silicon-Containing Macrocyclic Peroxides Chemists serendipitously discover that the linear silyl peroxides they set out to make form large rings instead by Stephen K. Ritter ...