2023年2月2日，该研究工作以Modular Biomimetic Strategy Enabled Discovery of Simplified Pseudo-Natural Macrocyclic P？ Glycoprotein Inhibitors Capable of Overcoming Multidrug Resistance为题发表于 Journal of Medicinal ...

FURTHER READING Tsantrizos, Y. S. et al. Macrocyclic inhibitors of the NS3 protease as potential therapeutic agents of hepatitis C virus infection. Angew. Chem. Int. Ed. Engl. 42, 1356–1360 (2003) ...

Macrocyclic drugs are an emerging class of therapeutics that promise to open up drug target spaces which are poorly addressed by small chemical entities and larger biologics. Cyclosporin is the ...

Macrocyclic compounds are cyclic molecules with a structure of 12 or more atoms. In the past decades, macrocycles have received increasing attention in drug development.

Hepatocyte growth factor (HGF) is involved in cancer progression through MET receptor signaling. Here, HiP-8, a 12 amino-acid macrocyclic peptide, was identified to selectively recognize active ...

Macrocyclic compounds are cyclic molecules with a structure of 12 or more atoms. In the past decades, macrocycles have received increasing attention in drug development.

New cyclization reactions for synthesizing macrocyclic drug leads Date: August 21, 2019 Source: Ecole Polytechnique Fédérale de Lausanne Summary: Scientists have developed a new method to ...

Macrocyclic compounds are ring-shaped molecules made by connecting two ends of linear molecules. One of their unique and exciting properties is that their cyclical configuration reduces their ...

CHALFONT ST GILES, England--(BUSINESS WIRE)--The U.S. Food and Drug Administration (FDA) has approved Clariscan™, a macrocyclic, ionic, gadolinium-based, MRI contrast agent, expanding the GE ...

Ensemble Therapeutics is leveraging its DNA-Programmed Chemistry™ (DPC™) platform to develop a class of synthetically engineered small molecule macrocyclic drugs known as Ensemblins, which it ...

Macrocyclic peptides are promising candidates for pharmaceuticals, but their screening is difficult. Scientists have now developed an easy-to-use, high-throughput screening assay for cyclic ...