The team also used a special kind of light to check the amount of a pigment called lipofuscin, which increases as worms get older. After treating the worms with doxycycline for 13 days, they found ...

Apocrine chromhidrosis is caused by a buildup of lipofuscin granules in the apocrine sweat glands. Lipofuscin, known as an ...

Dr Mike Boulton, Department of Ophthalmology, Manchester Royal Eye Hospital, Oxford Road, Manchester M13 9WH. BACKGROUND Lipofuscin granules in the retinal pigment epithelium are lipid protein ...

The most profound change of human RPE with age is the enormous accumulation of RPE lipofuscin, a complex mixture of undigested, oxidized POS derivatives trapped in RPE lysosomes. Oxidative damage ...

Cellular autofluorescence emitted by cellular endogenous molecules (such as NADH, flavins and lipofuscin) can mask the ...

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed ...

As a consequence, damaged or apoptotic epithelial cells are engulfed by macrophages, where intracellular digestion results in residual lipofuscin bodies, which are responsible for the characteristic ...

It represents Ocugen’s modifier gene therapy approach, which is based on Nuclear Hormone Receptor (NHR) RORA that regulates pathway links to Stargardt disease such as lipofuscin formation, oxidative ...

1 Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia 2 The “Russian Clinical Research Center for Gerontology” of the Ministry of Healthcare of the ...

Syndromic eye diseases are complex disorders of ophthalmologic interest in which the involvement of the eye is but one of the cardinal features of the disease. There are myriad syndromic eye ...

STGD1型Stargardt病是一种遗传性视网膜退行性疾病，与突变的ATP结合盒，亚科A，成员4(ABCA4)基因有关。STGD1是幼年黄斑变性最常见的形式，发病于儿童时期至成年早期或中期，可导致进行性、不可逆 ...