The hyperfunction theory, an alternative idea that has emerged in biogerontology in recent years, allows that molecular damage does occur. The theory, however, also holds that such damage probably ...

HYPERFUNCTION of differentiated cells occurs when the synthesis of proteins and nucleic acids is in excess of the requirement for normal cellular growth and proliferation1–7. Whether the ...

A new research perspective was published in Aging (Aging-US) Volume 14, Issue 20, entitled, “Rapamycin treatment early in life reprograms aging: hyperfunction theory and clinical practice.” ...

This finding was of particular significance in that only 1 patient, a woman with active acromegaly, had a basal urinary 17-ketosteroid level sufficiently above the normal range to alert the ...

In most patients with malignant neoplasms, adrenocortical hyperfunction is not clinically manifest. When the picture of hyperadrenocorticism is present it may take one of two rather distinct forms.