To investigate the involvement of microRNAs (miRNAs) in intrinsic drug resistance to hydroxycamptothecin (HCPT) of six gastric cancer cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and ...

Background: AR-67 is a 3 rd generation camptothecin analog with superior stability of its active lactone form (>85%). This stability has been credited in part to the -R 10 hydroxyl group (-OH); a ...

Background: AR-67 is a 3 rd generation camptothecin analog selected for development based on the high in vitro stability of its pharmacologically active lactone form and high potency in preclinical ...