总之，HOTAIR是一种长的非编码RNA，已被确定为BC转移、耐药和预后的关键调节因子。 它的上调与侵袭性BC表型的发展有关，如TNBC，以及不良的患者 ...

研究揭示HOTAIR通过激活Notch通路促进TSCCa放疗抵抗的分子机制：1)放疗诱导的DNA损伤修复增强；2)细胞代谢重编程；3)凋亡逃逸和自噬激活；4)肿瘤微环境重塑。 特别值得注意的是，HOTAIR与Notch通路的Jagged1配体存在正反馈调节，形成促放疗抵抗的恶性循环。 【结论】 ...

HotAir.com — combined with Townhall.com — creates the largest conservative commentary, analysis, and news network on the Web with more than 3 million unique readers.

While HotAir is a regular news site, Twitchy compiles Twitter messages to form a streaming commentary feed. Malkin announced the deal on Twitchy on Tuesday. The acquisition price was not disclosed.