在眼科疾病领域，Fuchs 内皮角膜营养不良（FECD）是一种令人头疼的双侧、渐进性角膜内皮疾病。它的典型特征是角膜中央会出现一种名为 “滴状赘生物（guttae）” 的细胞外基质（ECM）赘生物。随着病情发展，guttae 数量不断增加，尤其是在角膜中央区域，当发展到一定阶段，会出现 “融合性 guttae ...

The guttae can be difficult to find, but high magnification and an appropriate light setting on the slit lamp makes identifying them fairly easy, Dr. Lee said.

“In fact, there are no good model systems to use to test potential new therapeutics for FECD before human clinical trials,” Patel says. “The most significant outcome from this work will be that we ...

Fuchs's corneal dystrophy (FCD) is a leading cause of corneal transplantation and affects 5% of persons in the United States who are over the age of 40 years. Clinically visible deposits called gut ...

The study included 3,281 eyes of 1,971 patients classified according to disease severity: stage 0, no guttae; stage 1, guttata cornea without edema; stage 2, mild Fuchs' dystrophy; and stage 3 ...

Guttae are bumps on the back surface of the cornea that grow larger as the disease progresses. During Descemet's stripping automated endothelial keratoplasty (DSAEK), Descemet's membrane and the ...