Ectodomain of CA IX is detectable in the culture medium and body fluids of cancer patients, but the mechanism of its shedding has not been thoroughly investigated.

Cadherins are transmembrane proteins that mediate adhesion between cells in the solid tissues of animals. Here we present the 3.1 angstrom resolution crystal structure of the whole, functional ...

The C83 ectodomain is shorter by 16 amino acids. The data also suggest that antibodies and peptides target the N-terminal tip of C99 block γ-secretase action by bulking up the substrate’s ectodomain, ...

Before AI, scientists had already identified upwards of 150 substrates for γ-secretase, using computational and biochemical methods (Hemming et al., 2008; Güner and Lichtenthaler, 2020). The secretase ...