Dihydropteroate synthase (DHPS) is a crucial enzyme in the folate biosynthetic pathway, catalysing the formation of essential folate cofactors that underpin DNA synthesis and cellular functioning.

To investigate the possible association between different prophylactic sulfa drugs and the genotype of the Pneumocystis proved dihydropteroate synthase (DHPS) gene, we examined DHPS polymorphisms in ...

Edmund M. Wise, Martha M. Abou-Donia, Sulfonamide Resistance Mechanism in Escherichia coli: R Plasmids Can Determine Sulfonamide-Resistant Dihydropteroate Synthases, Proceedings of the National ...

How do sulfonamides work? They work by inhibiting an enzyme called dihydropteroate synthase (DHPS). DHPS helps produce folic acid, which bacteria need in order to proliferate.