Dihydropteroate synthase (DHPS) is a crucial enzyme in the folate biosynthetic pathway, catalysing the formation of essential folate cofactors that underpin DNA synthesis and cellular functioning.

The sulfonamide antibiotics inhibit dihydropteroate synthase (DHPS), a key enzyme in the folate pathway of bacteria and primitive eukaryotes. However, resistance mutations have severely compromised ...

How do sulfonamides work? They work by inhibiting an enzyme called dihydropteroate synthase (DHPS). DHPS helps produce folic acid, which bacteria need in order to proliferate.