为解决现有杀线虫化合物退市带来的农业防控缺口，研究人员通过一锅法亲核加成反应合成了一系列螺环 (DHPM-靛红)衍生物（IVa-IVh），并系统评估其对南方根结线虫（Meloidogyne incognita）的杀卵和幼虫活性。其中IVe在1500 ppm浓度下实现98%卵孵化抑制，IVf更在750 ppm时引发100%幼虫致死率。计算机模拟揭示 ...

该研究证实DHPM通过机械力（层流剪切、空化效应等）精准调控蛋白结构，建立"压力-循环次数-功能特性"的定量关系。 特别值得注意的是，150 MPa-3次处理在溶解度、乳化性等关键指标上达到最佳平衡，而200 MPa处理更适合需要高热稳定性的应用场景。

We present here a protocol for the synthesis of the dihydropyrimidine (DHPM) derivative monastrol, which is known to be a specific mitotic kinesin Eg5 inhibitor. By applying controlled microwave ...

Here we report the generation of a small focused library of 12 diversely functionalized dihydropyrimidine (DHPM) derivatives via one-pot three-component Biginelli cyclocondensation of β ...

In 2010, she retired from the U.S. Marine Corps as a colonel, having served two combat deployments. Before her time at DHPM, she spent eight years at King & Ballow, the last two of them as partner.

University of Agricultural Sciences, Dharwad has achieved national recognition for developing two crop breeds, Kharif Sorghum hybrid DSH-6 (CSH-49) and proso millet variety CPRMV-1 (DHPM 60-4 ...