Spontaneous deamination of 5-methyl-cytosines can escape detection by the DNA repair system, which makes methylated CpG dinucleotides mutational hotspots. As a result, over evolutionary time ...

If an organism cannot use lactose as a food source it will be forced to use the amino acids / proteins in the media. The deamination of the amino acids creates NH 3, a weak base, which causes the ...

At the mechanistic level, CSR is an intricately choreographed interplay of transcription, DNA deamination, and DNA repair. The IgH locus comprises several constant region (C H) genes, each of which is ...

In the liver, ammonia is formed by the deamination of amino acids. It is highly toxic and cannot be allowed to accumulate in the body. Excess ammonia is converted to urea. Urea and water are ...

It is commonly found at the wobble position of anticodons, allowing for greater flexibility in base pairing. Inosine is also formed by the deamination of adenosine, a process catalyzed by enzymes ...

B) DNA methylation involves conversion of unmethylated cytosine to 5-methyl-cytosine (5mC). A proposed method for DNA demethylation involves sequential oxidation and deamination of 5mC, followed by ...

In the liver ammonia is formed by the deamination of amino acids. It is highly toxic and cannot be allowed to accumulate in the body. Excess ammonia is converted to urea. Urea and water are ...

Adenine plays a crucial role in maintaining the integrity of genetic information. Mutations can occur when adenine is altered or mismatched with other bases. For example, the deamination of adenine ...

Semin Liver Dis. 2008;28(1):70-80. New technological advances have allowed a better knowledge of the disturbances present in the brain in HE, not only in experimental models, but also in patients ...

It is difficult to predict with a sufficient degree of accuracy using the techniques currently available whether a biopharmaceutical will be immunogenic when tested in humans and if so, to what ...