Cryoprotectants safeguard slowly frozen cells/tissues by 4 mechanisms: reducing high salt concentrations, decreasing cell shrinkage, reducing the fraction of the solution that is frozen and/or ...

Cryoprotectants (CPAs) are a series of biomaterials to reduce cryoinjuries. To achieve the high efficiency of RBC cryopreservation, suitable CPAs should be added before freezing.

Understanding how even this 'simple' polymer works to control ice re-crystallization is a major step forward to discover new cryoprotectants, and ultimately to use them in the real world." ...

Tissue frozen without cryoprotectants is susceptible to damage from the formation of ice crystals, ultimately resulting in loss of function and cell death. This is why German’s team used a ...

When biological material is frozen, cryoprotectants are used to prevent the damage associated with the formation of ice during the freezing process. New polymeric cryoprotectants are emerging ...

Nature has evolved sugars, amino acids, and special antifreeze proteins as cryoprotectants. People use organic solvents and synthetic polymers as additives to prevent cell cultures from freezing ...

As of right now, options are limited: as a review of cryoprotectants in Rejuvenation Research noted in 2015, our best bets are on molecules like ethylene glycol and propylene glycol — literally ...

So the hunt is still on for better cryoprotectants. “When you look at the structure of a normal protein, it’s like alphabet soup—a large number of different amino acids in a complex sequence ...

In the paper, researchers at The University of British Columbia describe work to assess how spray drying and freeze-drying affect the structures of insulin-loaded nanoparticles, both with and ...