The fidelity of DNA polymerases depends on conformational changes that promote the rejection of incorrect nucleotides before phosphoryl transfer. Here, we combine single-molecule FRET with the use ...

Time-resolved fluorescence resonance energy transfer reveals conformational energetics of a bacterial cyclic nucleotide-gated ion channel.

A single hydrophobic interaction drives allosteric gate-opening of the archaeal 20S proteasome, identifying a specific new target for therapeutic drug design.

Conformational changes in proteins, which occur at the nanoscale, are fundamental to processes ranging from enzyme catalysis and chemical signaling to cell division and differentiation.

Alan Cooper, Conformational fluctuation and change in biological macromolecules, Science Progress (1933-), Vol. 66, No. 264 (Winter 1980), pp. 473-497 ...

Microsoft’s artificial intelligence tool BioEmu can predict the multiple conformational states of a protein, giving insight into how a protein moves and its potential function. Credit: Frank Noé ...

Additionally, conformational changes that were associated with the activation or inactivation of spike protein proceeded more slowly in SARS-CoV-2 as compared to SARS-CoV-1.