An alternative to using standard glucocorticoids is the synthetic dissociative steroid vamorolone (Agamree), which was ...

DEAR PEOPLE’S PHARMACY: I have been taking prednisone since 2008 for an autoimmune disease, and I may spend the rest of my life coping with the adverse effects. The major problem now appears to be ...

Long-term bisphosphonate therapy can change bones at the microscopic level to make them more susceptible to the rare catastrophic transverse breaks known as atypical femoral fractures (AFFs ...

Each bisphosphonate registration trial enrolled 3000 to 7500 patients and was powered for the demonstration of fracture efficacy, whereas the long-term extension studies, with enrollments ranging ...

In the CPRD cohort, researchers observed 5,234 deaths among bisphosphonate users (27%) during 45,690 person-years of follow-up, and 85,105 deaths among nonusers (40%) during 915,867 person-years ...

Adding a bisphosphonate to steroid therapy may extend the life of boys with Duchenne muscular dystrophy by about a decade and, in some cases, considerably longer, a new study suggests.

In 2010, the FDA required makers of bisphosphonate drugs to add a warning to their labels about a small increased risk of atypical femur fractures after an American Society for Bone and Mineral ...

Mavrokokki A, Cheng A, Stein B, et al. The nature and incidence of bisphosphonate associated osteonecrosis of the jaws in Australia. J Oral Maxillofac Surg. 2007;65:415-423.

On the basis of our studies, we estimated that bisphosphonate treatment would result in an annual rate of 2.3 subtrochanteric or diaphyseal fractures per 10,000 patient-years in untreated women ...

January 8, 2008 — Temporary or permanent discontinuation of bisphosphonate therapy should be considered in patients who present with severe musculoskeletal pain, the US Food and Drug ...

Bisphosphonate-mediated inhibition of osteoclast function seems to decrease bone resorption and inhibit normal bone turnover remodelling. Bone resorption and remodelling play an essential role in ...

Bisphosphonate associated osteonecrosis of the jaws (BONJ) has been well documented recently in relation to intravenous preparations of the drug. These are most commonly used as part of the ...