Adeno-associated virus serotype 9 (AAV9) is currently considered the benchmark vector for clinical cardiac gene transfer applications but can entail severe hepatotoxicity because of its strong ...

With approval to proceed, the Phase II trial (NCT06092034) of RP-A501 for Danon disease restarts under an optimized dosing ...

Gene Therapy MarketThe Adeno-Associated Virus (AAV) Gene Therapy Market has emerged as a transformative segment within the ...

In the wake of multiple patient deaths from liver injuries related to Sarepta Therapeutics’ AAV gene therapy platform, some ...

Study: Adeno-associated virus 2 infection in children with non-A-E hepatitis. Image Credit: ART-ur/Shutterstock This news article was a review of a preliminary scientific report that had not ...

Valoctocogene roxaparvovec (AAV5-hFVIII-SQ) is an adeno-associated virus 5 (AAV5)–based gene-therapy vector containing a coagulation factor VIII complementary DNA driven by a liver-selective ...

One such virus, the adeno-associated virus (AAV), is the secret to gene therapy success. AAVs are small viruses of no more than 5,000 kilobases. Scientists often equip AAVs with modified gene ...

Touching Base is the dynamic podcast series from the editors of GEN. Each episode features a rotating case of senior editors—including John Sterling, Kevin Davies, Julianna LeMieux, Alex ...

Adeno-associated viruses are tiny bits of DNA they can't copy themselves until they're in the presence of another virus, usually adenovirus or herpes. They belong to a family of viruses called ...