Findings from St. Jude Children's Research Hospital demonstrate that virtual memory T cells, a specialized group of immune ...

X-linked severe combined immunodeficiency disease (X-SCID) is a rare genetic disorder characterized by profound defects in T-cell, B-cell, and natural killer (NK) cell function, caused by ...

NEW ORLEANS -- Genetic therapy appeared to restore the immune system of patients with X-linked severe combined immunodeficiency (SCID), but without leading to leukemia as a side effect, researchers re ...

A murine X-SCID model was created by targeted disruption of the X-linked γc gene. 8 The X-SCID mice were back-crossed to a C57BL/6-Ly5.2 background and an inbred colony was established.

The syndrome X-SCID is caused by faulty expression of the γ-chain of the interleukin-2 receptor (IL2RG), which results in diminished lymphoid-cell survival and proliferation. Gene therapy can ...

Infants with X-SCID, caused by mutations in the IL2RG gene, are highly susceptible to severe infections. If untreated, the disease is fatal, usually within the first year or two of life.

This is the most frequent type of SCID with approximately 50% of the incidence. Mutation in the interleukin 2 receptor gamma (IL2RG) gene on X-chromosome is the primary cause for XSCID.

While X-SCID is extremely rare, scientists are also using gene therapy to create treatments for other, more common conditions including cancer and blindness.

Salk Institute. "Mouse Study Reveals Human X-SCID Gene Therapy Poses Substantial Cancer Risk." ScienceDaily. ScienceDaily, 1 May 2006. <www.sciencedaily.com / releases / 2006 / 04 / 060430002334.htm>.

Puck herself is credited with leading a team that discovered the gene responsible for X-linked severe combined immunodeficiency syndrome, or X-SCID, which afflicted the well-known Boy in the Bubble of ...

Several infants treated with autologous ex vivo gene therapy for newly diagnosed X-linked severe combined immunodeficiency (X-SCID) in a phase I/II trial have developed fully functioning immune ...

Long-term follow-up of 16 boys treated with gene therapy to correct the immune deficiencies ADA-SCID and X-SCID in a British study has shown that despite some heartbreaking setbacks along the way, ...