A murine X-SCID model was created by targeted disruption of the X-linked γc gene. 8 The X-SCID mice were back-crossed to a C57BL/6-Ly5.2 background and an inbred colony was established.

The syndrome X-SCID is caused by faulty expression of the γ-chain of the interleukin-2 receptor (IL2RG), which results in diminished lymphoid-cell survival and proliferation. Gene therapy can ...

NEW ORLEANS -- Genetic therapy appeared to restore the immune system of patients with X-linked severe combined immunodeficiency (SCID), but without leading to leukemia as a side effect, researchers re ...

X-linked severe combined immunodeficiency disease (X-SCID) is a rare genetic disorder characterized by profound defects in T-cell, B-cell, and natural killer (NK) cell function, caused by ...

A farm family from Dennison, Minnesota, received a heartbreaking diagnosis: their unborn son has a rare, deadly genetic disorder. But thanks to a selfless stranger, their baby's story is taking a ...

Salk Institute. "Mouse Study Reveals Human X-SCID Gene Therapy Poses Substantial Cancer Risk." ScienceDaily. ScienceDaily, 1 May 2006. <www.sciencedaily.com / releases / 2006 / 04 / 060430002334.htm>.

X-SCID is caused by mutations in the IL2RG gene, which governs the behaviour of a protein involved in the development of a number of immune-system cells. ADA-SCID results from the lack of an ...

Puck herself is credited with leading a team that discovered the gene responsible for X-linked severe combined immunodeficiency syndrome, or X-SCID, which afflicted the well-known Boy in the Bubble of ...

X-SCID is an inherited condition in which the body cannot produce the cells responsible for defending against infection: T-cells, B-cells, and natural killer (NK) cells.

A small clinical trial has shown that gene therapy can safely correct the immune systems of infants newly diagnosed with a rare, life-threatening inherited disorder in which infection-fighting immune ...

Long-term follow-up of 16 boys treated with gene therapy to correct the immune deficiencies ADA-SCID and X-SCID in a British study has shown that despite some heartbreaking setbacks along the way, ...

While X-SCID is extremely rare, scientists are also using gene therapy to create treatments for other, more common conditions including cancer and blindness.