他们发现，用2-溴铝酸盐(2-BP)——一种蛋白质酰基转移酶抑制剂——处理衰老的人类血管平滑肌细胞(VSMCs)与衰老表型的不同方面的变化有关，包括细胞增殖的恢复，DNA损伤标记物的减少和衰老相关的β-半乳糖苷酶活性的下调。 假设抑制蛋白质棕榈酰化可以调节 ...

In the panvascular system, hypoxia-inducible factors (HIFs) can lead to excessive activity of vascular smooth muscle cells (VSMCs), presenting a phenotype of proliferation and migration in ...

本研究首次阐明了S100A4对TAD发育的影响。TAD发病时，S100A4表达增加，伴有VSMCs表型转变和ECM弹性纤维沉积减少。 在 45 岁时前列腺特异性抗原（PSA ...

In atherosclerosis, the vascular smooth muscle cell (VSMC) contributes to vessel wall inflammation and lipoprotein retention, as well as to the formation of the fibrous cap that provides stability ...

They showed that treatment of senescent human vascular smooth muscle cells (VSMCs) with 2-bromopalmitate (2-BP) - an ...

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science ...

The study investigates the role of the deubiquitinase OTUB1 in vascular smooth muscle cells (VSMCs) within the context of ...

该工作对生物正交光催化标记化学进一步发展，实现了其在动物组织和临床来源的原代细胞的应用，并进行了原位线粒体蛋白质组解析。 本研究结果 ...

A recent study investigates the role of the deubiquitinase OTUB1 in vascular smooth muscle cells (VSMCs) within the context of atherosclerosis, a disease characterized by lipid accumulation and ...